Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), - download pdf or read online

By Taotao Zou

ISBN-10: 9811006563

ISBN-13: 9789811006562

This thesis specializes in the improvement of gold- and non-classical platinum-based anti-cancer brokers that exhibit distinctively diversified anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are capable of shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. specified chemical synthesis, in vitro and/or in vivo anti-cancer actions are truly offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) complicated with a combined diphosphine and bis(NHC) ligand exhibiting favorable balance and displaying major inhibition of tumor development in self sustaining mice types without observable unwanted effects; and (iii) a panel of strong luminescent cyclometalated platinum(II) complexes showing excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and phone apoptosis. those works spotlight the scientific strength that gold and platinum complexes provide for melanoma treatment.

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou


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